The Women’s Health Initiative, the study that has already linked hormone replacement therapy to an increased risk of stroke, heart attack and some cancers also uncovered a blood clot hazard for women on HRT. According to the widely published study, women taking estrogen plus progestin at the strength once commonly in use had a doubled risk of venous blood clots, which can travel to the lungs and cause death.

The study involved 16,608 post-menopausal women between the ages of 50 and 79. Findings showed the blood clot risk was highest for those who were overweight, and that a genetic disposition for clots as well as advancing age also increased the risk.

“The implications of these findings may be important for the use of postmenopausal hormone therapy in the treatment of menopausal symptoms among younger postmenopausal women,” the researchers concluded.

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